If you've just purchased your own Jagdpanzer E 100 and are now looking for some advice, let us first congratulate you for reaching the end of the German tank destroyer line! While it feels somewhat like a successor to the previous vehicles, it still has its own, unique gameplay.
If you've read the Tank Manuals of the preceding vehicles, we've often mentioned how the hull armour doesn't provide enough protection and only hull-down tactics could work properly. With this German behemoth, this is finally over. It shares the same hull as the normal E 100 heavy tank, and even the lower frontal plate is not that weak, especially when driving in a zig-zag pattern. The superstructure is thick but flat – be careful when engaging other tanks with high penetration power.
Of course, the Jagdpanzer E 100 doesn't really play like a tank destroyer lurking in the bushes and waiting for the best chance to strike. Instead, it's an assault gun meant for close combat, which is why it has such strong armour and high survivability. It can both push and defend, especially the latter, thanks to its frightening gun. Plan in advance where you want to go as you won't be able to change flanks later on.
The 17 cm Pak's penetration value and damage are among the highest in the entire game and are only surpassed by the FV215b (183) and FV4005 Stage II. The accuracy is no longer one of the strong points, even though it's still decent. The reload time is extremely long and the aiming time will force you to aim for some time; stay close to your target, where it doesn't matter as much.
With a reload and aiming time that long, you surely don't need to think twice about the equipment. Mounting a Tank Gun Rammer already makes a huge difference in terms of reload time, and having to aim for a shorter time increases the chance of a successful hit. Remember: two or three successful hits are already enough for a decent battle.
Just like the preceding vehicles, the Jagdpanzer E 100 requires the Repair skill in case the tracks get blown off. Especially in high-tier battles, the enemy will try to destroy them, making you vulnerable to further damage while you need to reload. Later on, the Brothers in Arms perk will prove useful – even a small bonus reduces the reload time significantly.